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The nasal mucosal late allergic reaction to grass pollen involves type 2 inflammation (IL-5 and IL-13), the inflammasome (IL-1β), and complement.


Leaker BR, Malkov VA, Mogg R, Ruddy MK, Nicholson GC, Tan AJ, Tribouley C, Chen G, De Lepeleire I, Calder NA, Chung H, Lavender P, Carayannopoulos LN, Hansel TT. Mucosal Immunol. 2017 Mar;10(2):408-420 Full text


A novel inhaled phosphodiesterase 4 inhibitor (CHF6001) reduces the allergen challenge response in asthmatic patients.


Singh D, Leaker B, Boyce M, Nandeuil MA, Collarini S, Mariotti F, Santoro D, Barnes PJ. Pulm Pharmacol Ther. 2016 Oct;40:1-6 Full text


A novel flow cytometric-based method to measure kinase inhibition in sputum from COPD subjects.


Nicholson GC, Holloway RA, Leaker BR, Kilty I, Salganik M, Tan L, Barnes PJ, Donnelly LE.
BMJ Open Respir Res. 2016 Jun 22;3(1) Full text


Using magnetic resonance imaging to quantify the inflammatory response following allergen challenge in allergic rhinitis.


Leaker BR, Scadding G, Jones CR, Barnes PJ. Immun Inflamm Dis. 2015 Sep 17;3(4):445-54 Full text


Bronchoabsorption; a novel bronchoscopic technique to improve biomarker sampling of the airway.


Leaker BR, Nicholson GC, Ali FY, Daudi N, O’Connor BJ, Barnes PJ. Respir Res. 2015 Sep 4;16:102 Full text


The novel inhaled glucocorticoid receptor agonist GW870086X protects against adenosine-induced bronchoconstriction in asthma.


Leaker BR, O’Connor B, Singh D, Barnes PJ. JACI 2015 Aug 136(2):501-2 Full text


The effects of the novel SHIP1 activator AQX-1125 on allergen-induced responses in mild to moderate asthma.


Leaker BR, O’Connor B, Barnes PJ, Tam P, Neville J, Mackenzie LF, MacRury T. Clin Exp Allergy 2014, 44:1146 Full text


Efficacy and safety of nebulized glycopyrrolate for administration using a high efficiency nebulizer in patients with chronic obstructive pulmonary disease.


Leaker BR, Barnes PJ, Tutuncu A, Singh D. Br J Clin Pharmcol 2014, 79:492 Full text


The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthmatics


Leaker BR, Singh D, Barnes PJ, Ali F, O’Connor B. BMC Pulm Med 2014, 14:166 Full text


Setipiprant, a selective CRTH2 antagonist, reduces allergen-induced airway responses in allergic asthmatics.


Diamant Z, Sidharta PN, Singh D, O’Connor B, Leaker BR, Zuiker R. Clin Exp Allergy 2014 , 44:1044 Full text


Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist.


Leaker BR, Barnes PJ, O’Connor B. Respir Res 2013, 14:137 Full text


Rapid effects of extrafine beclomethasone dipropionate/formoterol fixed combination inhaler on airway inflammation and bronchoconstriction in asthma: a randomised controlled trial.


O’Connor BJ, Collarini S, Poli G, Brindicci C, Spinola M, Acerbi D, Barnes PJ, Leaker BR. BMC Pulm Med 2011, 11:60 Full text


Safety of Regadenoson, an A2A receptor agonist for myocardial perfusion imaging in asthmatic patients: a randomised double blind placebo controlled trial.


Leaker BR, O’Connor B, Hansel TT, Barnes PJ, Meng L, Mathur VS, Lieu HD. J Nuc Cardiol 2008, 15:329 Full text

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